Vetenskapliga artiklar

White paper Foxy-5

MEHDAWI LM, PRASAD CP, EHRNSTRÖM R, ANDERSSON T and SJÖLANDER A. Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH via JNK1 and induces differentiation of colon cancer cells.

Molecular Oncology 10(9):1415-1429, 2016.

Sherwood V, Chaurasiya S, Ekström E, Guilmain W, LIu Q, Hansson K, Agnarsdóttir M, Bergqvist M, Jirström K, Ponten F, James P and Andersson t.
WNT5A-Mediated b-catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism.

Carcinogenesis  35(4):784-794, 2014.

PRASAD CP, CHAURASIYA SK, AXELSSON L and ANDERSSON T. WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells.

Molecular Oncology 7:870-883, 2013.

SAND-DEJMEK J, EHRNSTRÖM R, BENDAHL P-O, ANDERSSON T and RYDEN L. The prognostic significance of Wnt-5a expression in primary breast cancer is extended to premenopausal women.

PLoS ONE 8:e70890 (pages 1-10), 2013.

KHAJA ASS, EGEVAD L, Helczynski L, WIKLUND P, ANDERSSON T &BJARTELL A. Emphasizing the role of Wnt5a protein expression to predict favourable outcome after radical prostatectomy in patients with low-grade prostate cancer.  

Cancer Medicine 1:96-104, 2012. (doi: 10.1002/cam4.5)

JENEI V, SHERWOOD V, HOWLIN J, LINNSKOG R, SÄFHOLM A, AXELSSON L, & ANDERSSON T: A t-butyloxycarbonal modified Wnt-5a-derived hexapeptide functions as a potent antagonist of Wnt-5a-dependent melanoma cell invasion.

Proc. Natl. Acad. Sci. USA 106:19473-19478, 2009.

MEDREK C, LANDBERG G, ANDERSSON T & LEANDERSSON K: Wnt-5a-CKIa signalling promotes b-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells.

J. Biol. Chem. 284:10968-10979, 2009.  

SÄFHOLM A, TUOMELA J, ROSENKVIST J, DEJMEK J, HÄRKÖNEN P & ANDERSSON T: The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. 

Clinical Cancer Research 14(20):6556-6563, 2008.

SÄFHOLM A, LEANDERSSON K, DEJMEK J, KAMP-NIELSEN C, VILLOUTREIX B & ANDERSSON T: A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. 

J. Biol. Chem. 281;2740-2749, 2006.

DEJMEK J, DEJMEK A, SÄFHOLM A, SJÖLANDER A & ANDERSSON T: Wnt-5a protein expression in primary Dukes B colon cancer s identifies a subgroup of patients with good prognosis.

Cancer Research (highlighted article) 65;9142-9146, 2005.

JÖNSSON M, DEJMEK J, BENDAHL P-O & ANDERSSON T: Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. 

Cancer Research 62:409-416, 2002.